Causal Mediation Analysis

A 2-Day Seminar Taught by Tyler VanderWeele, Ph.D.  


This seminar will focus on some of the recent developments in causal mediation analysis and will provide practical tools to implement those techniques. Mediation analysis deals with the mechanisms and pathways by which causal effects operate. The course will discuss the relationship between traditional methods for mediation in the biomedical and social sciences and new methods of causal inference for dichotomous, continuous, and time-to-event outcomes.

We will also consider when standard approaches to mediation analysis are valid and when they are not valid. These approaches will be extended to more complex settings. The no-confounding assumptions needed for these techniques will be discussed in detail. SAS, SPSS and Stata macros to implement mediation methods will be demonstrated and distributed to course participants.

Other topics include the use and implementation of sensitivity analysis (to assess how sensitive conclusions are to violations of assumptions) and extensions to multiple mediators.


Who should attend?

Course prerequisites: Familiarity with linear and logistic regression. Some knowledge of counterfactual or potential outcomes notation is helpful, but not necessary. Software descriptions will be given in SAS, Stata, SPSS, and R but knowledge of these is not required for the course.


COMPUTING

In all cases, methods will be illustrated using software, with SAS, Stata, SPSS, and R examples and syntax. This is a hands-on course with at least one hour each day devoted to carefully structured and supervised assignments.  To do the exercises, you will need to bring your own laptop computer with a recent version of SAS or Stata or SPSS or R.


LOCATION, FORMAT AND MATERIALS

The class will meet from 9 am to 5 pm each day with a 1-hour lunch break at Temple University Center City, 1515 Market Street, Philadelphia, PA 19103. 

Participants receive a bound manual containing detailed lecture notes (with equations and graphics), examples of computer printout, and many other useful features. This book frees participants from the distracting task of note taking. 


Registration and lodging

The fee of $995.00 includes all seminar materials. The early registration fee of $895.00 is available until March 21.

Refund Policy
If you cancel your registration at least two weeks before the course is scheduled to begin, you are entitled to a full refund (minus a processing fee of $50). 

Lodging Reservation Instructions

A block of guest rooms has been reserved at the Club Quarters Hotel, 1628 Chestnut Street, Philadelphia, PA at a special rate of $154 per night. This location is about a 5 minute walk to the seminar location. In order to make reservations, call 203-905-2100 during business hours and identify yourself as part of the Statistical Horizons room block. For guaranteed rate and availability, you must reserve your room no later than Monday, March 20, 2017.

If you make reservations after the cut-off date ask for the Statistical Horizons room rate (do not use the code) and they will try to accommodate your request.


Outline

  1. Concepts and methods for mediation
  2. Sensitivity analysis
  3. Mediation with time-to-event outcome
  4. Multiple mediators
  5. Surrogate outcomes
  6. A unification of mediation and interaction